France head coach Fabien Galthie handed back-rower Sekou Macalou a first cap since 2017 on Thursday as he was forced to make 13 changes to his team to host Italy in the Autumn Nations Cup this weekend.
Macalou, 25, has been in form for club side Stade Francais this season and benefits from an agreement between the French Rugby Federation and the Top 14 league which stipulates a maximum of three appearances for each player during the end-of-year campaign.
He replaces skipper Charles Ollivon at openside as scrumhalf Baptiste Serin takes over the captain's armband at the Stade de France on Saturday.
The only two survivors from last Sunday's win at Scotland are winger Teddy Thomas and flyhalf Matthieu Jalibert.
There are Test debuts for centre Jean-Pascal Barraque, winger Gabin Villiere, locks Killian Geraci and Baptiste Pesenti as well as prop Rodrigue Neti.
Macalou's domestic team-mate Jonathan Danty will make his first international appearance since 2016 as fullback Brice Dulin last featured for his country three years ago.
Third-placed Italy trail les Bleus in the pool ahead of the final round of group games. A win for France would secure a place in next weekend's final.
15 Brice Dulin, 14 Teddy Thomas, 13 Jean-Pascal Barraque, 12 Jonathan Danty, 11 Gabin Villiere, 10 Matthieu Jalibert, 9 Baptiste Serin, 8 Anthony Jelonch, 7 Sekou Macalou, 6 Cameron Woki, 5 Baptiste Pesenti, 4 Killian Geraci, 3 Dorian Aldegheri, 2 Peato Mauvaka, 1 Rodrigue Neti
Substitutes: 16 Teddy Baubigny, 17 Hassane Kolignar, 18 Uini Atonio, 19 Cyril Cazeaux, 20 Swan Rebbadj, 21 Baptiste Couilloud, 22 Louis Carbonel, 23 Yoram Moefana